Cronic non-bacterial osteomyelitis (CNO) in a cohort of pediatric patients: clinical, biological and radiological response to treatment with Anakinra

Materials and methods Seven patients (4 females and 3 males) with refractory CNO were treated with anakinra for at least 6 months in our institution. Response to treatment was evaluated assessing clinical manifestations (pain, local swelling, functional impairment), laboratory findings (C-reactive protein (CRP)), erythrocyte sedimentation rate (ESR)) and serum amyloid A level (SAA))) and number of bone lesions on TC-99 BS at the start of treatment and at 6 months.